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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Tsukida K, Akutsu K, Saiki K

J Nutr Sci Vitaminol (Tokyo). 1975;21(6):411-20. doi: 10.3177/jnsv.21.411.

The natural abundance carbon-13 nmr of vitamins D (D2 and D3) and several isomers (5, 6-trans-vitamin D2, isotachysterol2 and isovitamin D2) have been completely assigned by employing off-resonance noise-decoupling, acetylation shifts, and lanthanide-induced shifts experiments. The last two techniques were especially useful for the present study. 2. Carbon-13 nmr spectral characteristics of the three main conjugated triene moieties (SE-Z-SZ, SE-E-SZ, or SE-E-SE), involved in the molecules of vitamin D and its isomers, were revealed. Thus, the striking dependence of the shieldings on molecular geometries and high sensitivity of the resonances to the environments of conjugated systems were surveyed. 3. Conformational preferences in solutions of the hydroxyl groups in vitamins D2 and D3 as well as 5, 6-trans-vitamin D2 were conveniently determined.

通过采用非共振去耦、乙酰化位移和镧系元素诱导位移实验，已完全确定了维生素D（D2和D3）以及几种异构体（5,6-反式维生素D2、异速甾醇2和异维生素D2）的天然丰度碳-13核磁共振谱。后两种技术对本研究特别有用。2. 揭示了维生素D及其异构体分子中涉及的三个主要共轭三烯部分（SE-Z-SZ、SE-E-SZ或SE-E-SE）的碳-13核磁共振谱特征。因此，研究了屏蔽对分子几何结构的显著依赖性以及共振对共轭体系环境的高灵敏度。3. 方便地确定了维生素D2、D3以及5,6-反式维生素D2溶液中羟基的构象偏好。

Tsukida K, Akutsu K, Saiki K

J Nutr Sci Vitaminol (Tokyo). 1975;21(6):411-20. doi: 10.3177/jnsv.21.411.

The natural abundance carbon-13 nmr of vitamins D (D2 and D3) and several isomers (5, 6-trans-vitamin D2, isotachysterol2 and isovitamin D2) have been completely assigned by employing off-resonance noise-decoupling, acetylation shifts, and lanthanide-induced shifts experiments. The last two techniques were especially useful for the present study. 2. Carbon-13 nmr spectral characteristics of the three main conjugated triene moieties (SE-Z-SZ, SE-E-SZ, or SE-E-SE), involved in the molecules of vitamin D and its isomers, were revealed. Thus, the striking dependence of the shieldings on molecular geometries and high sensitivity of the resonances to the environments of conjugated systems were surveyed. 3. Conformational preferences in solutions of the hydroxyl groups in vitamins D2 and D3 as well as 5, 6-trans-vitamin D2 were conveniently determined.

通过采用非共振去耦、乙酰化位移和镧系元素诱导位移实验，已完全确定了维生素D（D2和D3）以及几种异构体（5,6-反式维生素D2、异速甾醇2和异维生素D2）的天然丰度碳-13核磁共振谱。后两种技术对本研究特别有用。2. 揭示了维生素D及其异构体分子中涉及的三个主要共轭三烯部分（SE-Z-SZ、SE-E-SZ或SE-E-SE）的碳-13核磁共振谱特征。因此，研究了屏蔽对分子几何结构的显著依赖性以及共振对共轭体系环境的高灵敏度。3. 方便地确定了维生素D2、D3以及5,6-反式维生素D2溶液中羟基的构象偏好。