Pandian Jeyaraj Durai, Venkateswaralu K, Thomas Sanjeev V, Sarma P S
Department of Neurology, Christian Medical College, Ludhiana, Punjab, India.
Epileptic Disord. 2007 Sep;9(3):285-91. doi: 10.1684/epd.2007.0120. Epub 2007 Sep 20.
We wanted to characterize the clinical profile and outcome of pregnancy in women with epilepsy due to neurocysticercosis (NCC) enrolled in the Indian Registry of Epilepsy and Pregnancy (IREP).
We identified all women with NCC in the IREP between January 2000 and September 2005. Age- and parity-matched patients without NCC were identified from the respective centers of IREP for comparison. Statistical analysis was performed using SPSS version 11.
There were 30 women with NCC (mean age 24.3 +/- 4 years) among 1071 registrations in the IREP. All the patients had NCC prior to the pregnancy. Fourteen (47%) NCC patients had calcified lesions and 16 (53%) had ring lesions in a CT scan of the brain. Compared to women without NCC, the NCC group had later age-at-onset of seizures (20.7 +/- 4.4 years, p = 0.008) and epilepsy (21.1 +/- 5.2 years, p = 0.01). They were more likely to have partial seizures (70% versus 30%, p = 0.002), an EEG without epileptiform abnormalities (50% versus 100%, p = 0.01), and better control of seizures before (47% versus 3%, p = 0.001) and during pregnancy (33% versus 10%, p = 0.02). Maternal and neonatal complications did not differ between the groups.
NCC is an uncommon cause of epilepsy in pregnant women enrolled in IREP. To be noted, as a limitation of our study, that the IREP is a hospital-based registry, which may not reflect global epilepsy characteristics of the community. The maternal and fetal outcome for NCC patients was not different from those women without NCC.
我们希望对印度癫痫与妊娠登记处（IREP）登记的神经囊尾蚴病（NCC）所致癫痫女性患者的临床特征及妊娠结局进行描述。
我们在IREP中确定了2000年1月至2005年9月期间所有患有NCC的女性。从IREP的各个中心挑选出年龄和产次匹配的无NCC患者进行比较。使用SPSS 11版进行统计分析。
IREP登记的1071例患者中有30例患有NCC的女性（平均年龄24.3±4岁）。所有患者在妊娠前就已患有NCC。脑部CT扫描显示，14例（47%）NCC患者有钙化灶，16例（53%）有环形病灶。与无NCC的女性相比，NCC组癫痫发作的起病年龄（20.7±4.4岁，p = 0.008）和癫痫起病年龄（21.1±5.2岁，p = 0.01）较晚。她们更易出现部分性发作（70%对30%，p = 0.002），脑电图无癫痫样异常（50%对100%，p = 0.01），且妊娠前（47%对3%，p = 0.001）和妊娠期间（33%对10%，p = 0.02）癫痫控制情况较好。两组间母婴并发症无差异。
NCC是IREP登记的妊娠女性癫痫的罕见病因。需要指出的是，作为我们研究的一个局限性，IREP是一个基于医院的登记处，可能无法反映社区的全球癫痫特征。NCC患者的母婴结局与无NCC的女性并无不同。
