LaJoie Josiane, Moshé Solomon L
Department of Neurology, New York University, New York, USA.
Epilepsia. 2004;45 Suppl 8:48-52. doi: 10.1111/j.0013-9580.2004.458007.x.
To describe the effects of pregnancy on seizures, the effects of seizures during pregnancy on the fetus, and the effects of antiepileptic drugs (AEDs) on fetal brain and development.
The available literature was reviewed and summarized.
There is a paucity of prospective studies. Retrospective studies indicate that, during pregnancy, alterations in seizure frequency can occur in an unpredictable fashion. Generalized tonic-clonic seizures may have adverse effects on the fetus. It is unclear whether complex partial seizures or absence seizures have negative consequences. AEDs may have potentially detrimental effects on the fetus and its subsequent development, but the full spectrum and clinical significance are under investigation. Monotherapy is strongly encouraged.
Dealing with the pregnant epileptic patient is a difficult and challenging task. Although there are several risks for the mother and the fetus, most epileptic women bear normal, healthy children.
描述妊娠对癫痫发作的影响、孕期癫痫发作对胎儿的影响以及抗癫痫药物（AEDs）对胎儿大脑和发育的影响。
对现有文献进行回顾和总结。
前瞻性研究较少。回顾性研究表明，孕期癫痫发作频率的改变可能以不可预测的方式发生。全身性强直阵挛发作可能对胎儿有不良影响。复杂部分性发作或失神发作是否有负面影响尚不清楚。抗癫痫药物可能对胎儿及其后续发育有潜在有害影响，但其全面影响和临床意义正在研究中。强烈鼓励采用单一疗法。
处理妊娠癫痫患者是一项困难且具有挑战性的任务。尽管对母亲和胎儿存在多种风险，但大多数癫痫女性会生下正常、健康的孩子。
