一种减毒活呼吸道合胞病毒疫苗在婴儿中的评估。

Evaluation of a live, attenuated respiratory syncytial virus vaccine in infants.

作者信息

Wright P F, Shinozaki T, Fleet W, Sell S H, Thompson J, Karzon D T

出版信息

J Pediatr. 1976 Jun;88(6):931-6. doi: 10.1016/s0022-3476(76)81044-x.

Abstract

Respiratory syncytial virus ts-1 is a live attenuated experimental vaccine which was administered intranasally to 25 infants 11 to 19 months of age. Clinical evaluation was carried out following a controlled, double-blind protocol which eliminated observer bias, assessed intercurrent illness, and was designed to detect virus transmission. At the low dose of virus of virus used (100 TCID50) 8 of the 25 recipients were successfully infected with RS virus ts-1 as determined by virus shedding or antibody response.

摘要

呼吸道合胞病毒ts-1是一种减毒活实验疫苗，通过鼻内给药方式接种于25名11至19个月大的婴儿。临床评估按照对照双盲方案进行，该方案消除了观察者偏差，评估了并发疾病，并旨在检测病毒传播。在所使用的低剂量病毒（100个半数组织培养感染剂量）下，根据病毒排出或抗体反应确定，25名接受者中有8人成功感染了呼吸道合胞病毒ts-1。