一名患有结核性淋巴结炎的免疫功能正常患者出现新型隐球菌脓肿和骨髓炎。

Cryptococcus neoformans abscess and osteomyelitis in an immunocompetent patient with tuberculous lymphadenitis.

作者信息

Al-Tawfiq J A, Ghandour J

机构信息

Internal Medicine Services Division, Dhahran Health Center, Saudi Aramco Medical Services Organization, Saudi Aramco, Dhahran, 31311, Saudi Arabia.

出版信息

Infection. 2007 Oct;35(5):377-82. doi: 10.1007/s15010-007-6109-9. Epub 2007 Sep 20.

DOI:10.1007/s15010-007-6109-9

PMID:17885733

Abstract

Infection with Cryptococcus neoformans usually occurs in immunocompromised hosts and may occur in immunocompetent patients. Of all cryptococcal infections, 10-40% of patients have no apparent immune deficiency. Disseminated disease may occur in up to 62% of HIV-seronegative patients with cryptococcosis; however, cryptococcal osteomyelitis is rare. Here, we report an immunocompetent patient with cryptococcal vertebral osteomyelitis and concomitant tuberculous lymphadenitis. The patient received 12 weeks of fluconazole and a 1-year course of anti-tuberculous agents, with complete recovery.

摘要

新型隐球菌感染通常发生在免疫功能低下的宿主中，也可能发生在免疫功能正常的患者身上。在所有隐球菌感染患者中，10% - 40%没有明显的免疫缺陷。在患有隐球菌病的HIV血清阴性患者中，高达62%可能会发生播散性疾病；然而，隐球菌性骨髓炎很罕见。在此，我们报告一例免疫功能正常的患者，患有隐球菌性脊椎骨髓炎并伴有结核性淋巴结炎。该患者接受了12周的氟康唑治疗和为期1年的抗结核药物治疗，最终完全康复。