Zheng Ying, Wu Feng-E
Chengdu Library of Chinese Academy of Sciences, Chengdu, China.
J Asian Nat Prod Res. 2007 Sep-Dec;9(6-8):545-9. doi: 10.1080/10286020600882692.
Besides a series of known sterols and triterpenoids, a new resorcinol (1) and a known resorcinol (2) have been isolated from ethanol extract of Ardisia maculosa for the first time. The structures of these resorcinol derivatives were elucidated as 2-methyl-5-(Z-heptadec-8-enyl) resorcinol and 5-Z-heptadec-8-enyl) resorcinol by HRESI-MS, NMR ((1)H, (13)C, HSQC, HMBC) experiments. In our in vitro assay, compounds 1 and 2 showed no antimicrobial activities, however, compound 2 exhibited cytotoxity activity against human cancer cell line with GI(50) value of 2.14 x 10(- 4) mmol/ml.
除了一系列已知的甾醇和三萜类化合物外,还首次从虎舌红乙醇提取物中分离出一种新的间苯二酚(1)和一种已知的间苯二酚(2)。通过高分辨电喷雾电离质谱(HRESI-MS)、核磁共振((1)H、(13)C、异核单量子相干谱(HSQC)、异核多键相关谱(HMBC))实验,将这些间苯二酚衍生物的结构鉴定为2-甲基-5-(Z-十七碳-8-烯基)间苯二酚和5-(Z-十七碳-8-烯基)间苯二酚。在我们的体外试验中,化合物1和2没有显示出抗菌活性,然而,化合物2对人癌细胞系表现出细胞毒性活性,其半数生长抑制浓度(GI(50))值为2.14×10^(-4)mmol/ml。