普萘洛尔对慢性布罗卡失语症伴命名障碍患者命名能力的影响。

Effect of propranolol on naming in chronic Broca's aphasia with anomia.

作者信息

Beversdorf David Q, Sharma Umesh K, Phillips Nicole N, Notestine Margaret A, Slivka Andrew P, Friedman Norman M, Schneider Sandra L, Nagaraja Haikady N, Hillier Ashleigh

机构信息

Department of Neurology, The Ohio State University Medical Center, Columbus, OH 43210, USA.

出版信息

Neurocase. 2007 Aug;13(4):256-9. doi: 10.1080/13554790701595471.

DOI:10.1080/13554790701595471

PMID:17886000

Abstract

Previous research suggests that the noradrenergic system modulates flexibility of access to the lexical-semantic network, with propranolol benefiting normal subjects in lexical-semantic problem solving tasks. Patients with Broca's aphasia with anomia have impaired ability to access appropriate verbal output for a given visual stimulus in a naming task. Therefore, we tested naming in a pilot study of chronic Broca's aphasia patients with anomia after propranolol and after placebo in a double-blinded crossover manner. Naming was better after propranolol than after placebo, suggesting a potential benefit from propranolol in chronic Broca's aphasia with anomia. Larger follow-up studies are necessary to further investigate this effect.

摘要

先前的研究表明，去甲肾上腺素能系统调节词汇语义网络的通达灵活性，普萘洛尔在词汇语义问题解决任务中对正常受试者有益。患有命名性失语的布罗卡失语症患者在命名任务中，针对给定视觉刺激获取适当言语输出的能力受损。因此，我们以双盲交叉方式，对慢性布罗卡失语症伴命名性失语患者进行了一项初步研究，测试了他们在服用普萘洛尔和安慰剂后的命名情况。服用普萘洛尔后的命名情况比服用安慰剂后更好，这表明普萘洛尔对慢性布罗卡失语症伴命名性失语可能有益。需要进行更大规模的随访研究来进一步探究这种效应。