细胞内β淀粉样蛋白在阿尔茨海默病中的作用。

The role of intracellular amyloid beta in Alzheimer's disease.

作者信息

Li Meng, Chen Liying, Lee Daniel Hong Seng, Yu Long-Chuan, Zhang Yan

机构信息

Laboratory of Neurobiology and State Key Laboratory of Biomembrane and Membrane Biotechnology, College of Life Sciences, Peking University, Beijing 100871, China.

出版信息

Prog Neurobiol. 2007 Oct;83(3):131-9. doi: 10.1016/j.pneurobio.2007.08.002. Epub 2007 Aug 19.

DOI:10.1016/j.pneurobio.2007.08.002

PMID:17889422

Abstract

Extracellular amyloid beta (Abeta) that confers neurotoxicity and modulates synaptic plasticity and memory function has been central to the amyloid hypothesis of Alzheimer's disease (AD) pathology. Like many other misfolded proteins identified in neurodegenerative disorders, Abeta also accumulates inside the AD neurons. This intracellular Abeta affects a variety of cellular physiology from protein degradation, axonal transport, autophagy to apoptosis, further documenting the role of Abeta in AD. Therapeutics targeting intracellular Abeta could be effective treatment for AD.

摘要

具有神经毒性并调节突触可塑性和记忆功能的细胞外淀粉样β蛋白（Aβ）一直是阿尔茨海默病（AD）病理学淀粉样假说的核心。与在神经退行性疾病中发现的许多其他错误折叠蛋白一样，Aβ也在AD神经元内积累。这种细胞内Aβ会影响从蛋白质降解、轴突运输、自噬到细胞凋亡等多种细胞生理过程，进一步证明了Aβ在AD中的作用。针对细胞内Aβ的疗法可能是治疗AD的有效方法。