Golde Todd E, Janus Christopher
Department of Neuroscience, Mayo Clinic, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA.
Neuron. 2005 Mar 3;45(5):639-42. doi: 10.1016/j.neuron.2005.02.013.
In this issue of Neuron, a study by Billings et al. points to intracellular Abeta as a possible cause of neuronal dysfunction. In a mouse model of Alzheimer's disease, Billings et al. link appearance of intraneuronal Abeta to cognitive impairments and then show that "clearance" of intraneuronal Abeta by anti-Abeta antibodies restores cognitive deficits.
在本期《神经元》杂志中，比林斯等人的一项研究指出细胞内β淀粉样蛋白可能是神经元功能障碍的一个原因。在阿尔茨海默病的小鼠模型中，比林斯等人将神经元内β淀粉样蛋白的出现与认知障碍联系起来，然后表明抗β淀粉样蛋白抗体对神经元内β淀粉样蛋白的“清除”可恢复认知缺陷。
