Boehringer Daniel, Ban Nenad
Institute of Molecular Biology and Biophysics, ETH Zurich, CH-8092 Zurich, Switzerland.
Cell. 2007 Sep 21;130(6):983-5. doi: 10.1016/j.cell.2007.09.002.
Protein synthesis is often regulated by structured mRNAs that interact with ribosomes. In this issue of Cell, Marzi et al. (2007) provide insights into the autoregulation of protein S15 by visualizing the folded repressor mRNA on the ribosome stalled in the preinitiation state. These results have implications for our understanding of the mechanism of translation initiation in general.
蛋白质合成通常受与核糖体相互作用的结构化信使核糖核酸（mRNA）调控。在本期《细胞》杂志中，马尔齐等人（2007年）通过可视化处于起始前状态停滞的核糖体上折叠的阻遏物mRNA，深入揭示了蛋白质S15的自我调控机制。总体而言，这些结果对我们理解翻译起始机制具有重要意义。
