神经递质受体的内吞作用：位置至关重要。

Endocytosis of neurotransmitter receptors: location matters.

作者信息

Puthenveedu Manojkumar A, Yudowski Guillermo A, von Zastrow Mark

机构信息

Department of Psychiatry and Department of Cellular & Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.

出版信息

Cell. 2007 Sep 21;130(6):988-9. doi: 10.1016/j.cell.2007.09.006.

DOI:10.1016/j.cell.2007.09.006

PMID:17889644

Abstract

Endocytosis of excitatory glutamate receptors from the postsynaptic plasma membrane plays a fundamental role in synaptic function and plasticity. In a recent study published in Neuron, Lu et al. (2007) describe protein interactions that link zones of receptor endocytosis directly to the postsynaptic scaffold and propose that local trafficking of receptors facilitated by these endocytic zones is required to maintain synaptic responsiveness.

摘要

兴奋性谷氨酸受体从突触后质膜的内吞作用在突触功能和可塑性中起着基础性作用。在最近发表于《神经元》杂志的一项研究中，卢等人（2007年）描述了将受体内吞区域直接与突触后支架相连的蛋白质相互作用，并提出这些内吞区域促进的受体局部运输对于维持突触反应性是必需的。