Gulati Vishal, Wallace Ron
Ross University School of Medicine, Miami Beach Community Health Center, 11645 Biscayne Boulevard, North Miami, FL 33181, USA.
Department of Anthropology, University of Central Florida, Orlando, FL 32816, USA.
Nanomaterials (Basel). 2012 Aug 6;2(3):217-250. doi: 10.3390/nano2030217.
This review examines the role of membrane rafts in neural disease as a rationale for drug targeting utilizing lipid-based nanoparticles. The article begins with an overview of methodological issues involving the existence, sizes, and lifetimes of rafts, and then examines raft function in the etiologies of three major neural diseases-epilepsy, Parkinson's disease, and Alzheimer's disease-selected as promising candidates for raft-based therapeutics. Raft-targeting drug delivery systems involving liposomes and solid lipid nanoparticles are then examined in detail.
本综述探讨了膜筏在神经疾病中的作用，以此作为利用脂质纳米颗粒进行药物靶向治疗的理论依据。文章首先概述了涉及膜筏的存在、大小和寿命的方法学问题，然后研究了膜筏在三种主要神经疾病（癫痫、帕金森病和阿尔茨海默病）病因中的作用，这三种疾病被选为基于膜筏治疗的有前景的候选对象。随后详细研究了涉及脂质体和固体脂质纳米颗粒的膜筏靶向给药系统。
