Cyhlarova E, Montgomery P, Ross M A, Richardson A J
Department of Physiology, Anatomy and Genetics, University of Oxford, Sherrington Building, Oxford, UK.
Prostaglandins Leukot Essent Fatty Acids. 2007 Aug;77(2):123-8. doi: 10.1016/j.plefa.2007.08.005. Epub 2007 Sep 24.
The niacin skin test reflects a flush and oedema owing to the production of prostaglandin D2 from arachidonic acid. A diminished response may indicate abnormalities in the phospholipid metabolism, which has been shown in schizophrenia. There is evidence that dyslexia might also involve phospholipid abnormalities, therefore we examined the skin response in 51 dyslexics and 45 controls. Four concentrations of aqueous methyl nicotinate were applied topically to the forearm. Flushing was rated using a seven-point scale at 3 min intervals over 21 min. Repeated measures ANOVA for the four concentrations across all seven time-points showed no significant effect of subject group, but when analyses were confined to the first 9 min, flushing was reduced in dyslexics. Significant group differences were also found for the lowest niacin concentration (0.0001M) across six out of seven time-points. The results indicate a slightly reduced and delayed response to niacin in dyslexia.
烟酸皮肤试验反映了由于花生四烯酸产生前列腺素D2而导致的脸红和水肿。反应减弱可能表明磷脂代谢异常，这在精神分裂症中已有显示。有证据表明诵读困难可能也涉及磷脂异常，因此我们检查了51名诵读困难者和45名对照者的皮肤反应。将四种浓度的烟酸甲酯水溶液局部涂抹在前臂上。在21分钟内每隔3分钟使用七点量表对脸红程度进行评分。对所有七个时间点的四种浓度进行重复测量方差分析，结果显示受试者组没有显著影响，但当分析仅限于前9分钟时，诵读困难者的脸红程度降低。在七个时间点中的六个时间点，对于最低烟酸浓度（0.0001M）也发现了显著的组间差异。结果表明诵读困难者对烟酸的反应略有减弱且延迟。
