Kerr Melissa, Cotton Sue, Proffitt Tina, McConchie Mirabel, Markulev Connie, Smesny Stefan, McGorry Patrick, Berger Gregor
Department of Psychiatry, ORYGEN Research Centre, University of Melbourne, Locked Bag 10 (35 Popular Road), Parkville, Victoria 3052, Australia.
Prostaglandins Leukot Essent Fatty Acids. 2008 Jul-Aug;79(1-2):15-9. doi: 10.1016/j.plefa.2008.06.001. Epub 2008 Jul 24.
Topical application of nicotinic acid results in erythema, and in some cases oedema of the skin, supporting a strong relationship between niacin sensitivity and prostaglandin D2. The aim of this study was to examine the inter-rater and intra-rater reliability of a 12-min niacin sensitivity test in healthy adults. Three raters assessed the skin reaction of 12 volunteers, over 3-min intervals across four niacin concentrations (0.1, 0.01, 0.001, and 0.0001), and over six sessions. Inter-rater reliability estimates ranged from 0.85 to 0.97 for the total niacin sensitivity score. Similar inter-rater reliability estimates were found for niacin sensitivity ratings by concentration and time. Intra-rater reliability estimates ranged from 0.63 to 0.93 for the total niacin sensitivity score. These data indicate that the 12-min topical niacin sensitivity test has excellent reliability.
局部应用烟酸会导致皮肤出现红斑，在某些情况下还会出现水肿，这支持了烟酸敏感性与前列腺素D2之间存在密切关系。本研究的目的是检验健康成年人12分钟烟酸敏感性试验在不同评估者之间和同一评估者内部的可靠性。三名评估者对12名志愿者的皮肤反应进行评估，在四个烟酸浓度（0.1、0.01、0.001和0.0001）下，每隔3分钟进行一次评估，共进行六次评估。不同评估者之间对总烟酸敏感性评分的可靠性估计范围为0.85至0.97。按浓度和时间对烟酸敏感性评级进行评估时，也发现了类似的不同评估者之间的可靠性估计。同一评估者内部对总烟酸敏感性评分的可靠性估计范围为0.63至0.93。这些数据表明，12分钟的局部烟酸敏感性试验具有出色的可靠性。
