自噬基因unc-51和bec-1是秀丽隐杆线虫正常细胞大小所必需的。
Autophagy genes unc-51 and bec-1 are required for normal cell size in Caenorhabditis elegans.
作者信息
Aladzsity István, Tóth Márton L, Sigmond Tímea, Szabó Emese, Bicsák Bertalan, Barna János, Regos Agnes, Orosz László, Kovács Attila L, Vellai Tibor
机构信息
Department of Genetics, Eötvös Loránd University, Budapest, Hungary.
出版信息
Genetics. 2007 Sep;177(1):655-60. doi: 10.1534/genetics.107.075762.
Abstract
Here we show that in the nematode Caenorhabditis elegans mutational inactivation of two autophagy genes unc-51/atg1 and bec-1/atg6/beclin1 results in small body size without affecting cell number. Furthermore, loss-of-function mutations in unc-51 and bec-1 suppress the giant phenotype of mutant animals with aberrant insulin-like growth factor-1 (insulin/IGF-1) or transforming growth factor-beta (TGF-beta) signaling. This function for unc-51 and bec-1 in cell size control and their interaction with these two growth modulatory pathways may represent a link between the hormonal and nutritional regulation of cell growth.
摘要
我们在此表明，在线虫秀丽隐杆线虫中，两个自噬基因unc-51/atg1和bec-1/atg6/beclin1的突变失活导致体型变小，但不影响细胞数量。此外，unc-51和bec-1的功能丧失突变抑制了具有异常胰岛素样生长因子-1（胰岛素/IGF-1）或转化生长因子-β（TGF-β）信号的突变动物的巨大表型。unc-51和bec-1在细胞大小控制中的这种功能以及它们与这两种生长调节途径的相互作用可能代表了细胞生长的激素调节和营养调节之间的联系。
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本文引用的文献
1
A Caenorhabditis elegans wild type defies the temperature-size rule owing to a single nucleotide polymorphism in tra-3.由于tra-3基因中的一个单核苷酸多态性，秀丽隐杆线虫野生型违背了温度-体型规则。
PLoS Genet. 2007 Mar 2;3(3):e34. doi: 10.1371/journal.pgen.0030034. Epub 2007 Jan 9.
2
Influence of autophagy genes on ion-channel-dependent neuronal degeneration in Caenorhabditis elegans.自噬基因对秀丽隐杆线虫中离子通道依赖性神经元变性的影响。
J Cell Sci. 2007 Mar 15;120(Pt 6):1134-41. doi: 10.1242/jcs.03401. Epub 2007 Feb 27.
3
Autophagy in neuronal cell loss: a road to death.
Bioessays. 2006 Nov;28(11):1126-31. doi: 10.1002/bies.20489.
4
C. elegans feeding defective mutants have shorter body lengths and increased autophagy.秀丽隐杆线虫进食缺陷型突变体的体长较短且自噬增加。
BMC Dev Biol. 2006 Aug 3;6:39. doi: 10.1186/1471-213X-6-39.
5
Generation of cell lines with tetracycline-regulated autophagy and a role for autophagy in controlling cell size.构建具有四环素调控自噬功能的细胞系以及自噬在控制细胞大小中的作用。
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6
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Cytokine Growth Factor Rev. 2006 Feb-Apr;17(1-2):59-74. doi: 10.1016/j.cytogfr.2005.09.007. Epub 2005 Nov 16.
7
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