Donadieu Jean, Roudier Candice, Saguintaah Magali, Maccia Carlo, Chiron Raphaël
Institut de veille sanitaire, Santé et Environnement, 12 rue du Val d'Osne, Saint Maurice 94415, France.
Chest. 2007 Oct;132(4):1233-8. doi: 10.1378/chest.07-0221. Epub 2007 Sep 21.
To determine the radiation exposure associated with CT scans in a population of patients with cystic fibrosis (CF).
We reviewed the medical charts of patients with typical CF who received regular medical management in a reference center from birth to March 31, 2004.
Among 80 patients with a total follow-up time of 1,231 person-years, 79 patients received a total of 269 CT scans, including 249 thoracic CT scans. The full parameters of the examination were available for 185 thoracic CT scans, allowing the effective dose (ED) and organ doses to be calculated. The ED was determined by the number of slices and the type of CT scans. The ED per thoracic CT scan was asymmetrically distributed (mean ED, 6.5 mSv; range 1.5 to 29.3 mSv). The mean doses delivered to the four most strongly exposed organs (lungs, breasts, bone marrow, and thyroid gland) were 18.6, 16.9, 5.2, and 3.5 mGy, respectively. The mean lifetime number of CT scans per patient was 3.2 (range, 0 to 13 scans), and the average lifetime ED was 19.5 mSv per patient (range, 2.2 to 75.8 mSv). Age at the first CT scan fell over the years, from 20 years for patients born before 1980 to 1.9 years for patients born after 1997.
The mean ED per CT scan in CF patients is about 6.5 mSv. Age at the first CT scan is lower in the most recent generation of patients. The lifetime ED of radiation received by CF patients, especially in the most recent generation, warrants long-term follow-up.
确定囊性纤维化（CF）患者群体中与CT扫描相关的辐射暴露情况。
我们回顾了在一个参考中心从出生至2004年3月31日接受常规医疗管理的典型CF患者的病历。
在80例患者中，总随访时间为1231人年，79例患者共接受了269次CT扫描，其中包括249次胸部CT扫描。185次胸部CT扫描的检查完整参数可用，从而能够计算有效剂量（ED）和器官剂量。ED由扫描层数和CT扫描类型决定。每次胸部CT扫描的ED分布不对称（平均ED为6.5 mSv；范围为1.5至29.3 mSv）。传递到四个受辐射最强器官（肺、乳房、骨髓和甲状腺）的平均剂量分别为18.6、16.9、5.2和3.5 mGy。每位患者CT扫描的平均终身次数为3.2次（范围为0至13次扫描），每位患者的平均终身ED为19.5 mSv（范围为2.2至75.8 mSv）。首次CT扫描的年龄多年来呈下降趋势，从1980年前出生的患者的20岁降至1997年后出生的患者的1.9岁。
CF患者每次CT扫描的平均ED约为6.5 mSv。最新一代患者首次CT扫描的年龄较低。CF患者接受的辐射终身ED，尤其是最新一代患者，需要长期随访。
