Pillard Fabien, Moro Cédric, Harant Isabelle, Garrigue Eric, Lafontan Max, Berlan Michel, Crampes François, de Glisezinski Isabelle, Rivière Daniel
Service d'Exploration de la Fonction Respiratoire et d'Exploration Fonctionnelle en Médecine du Sport, Hôpital Larrey, TSA 30030, 31059 Toulouse cedex 9, France.
Obesity (Silver Spring). 2007 Sep;15(9):2256-62. doi: 10.1038/oby.2007.268.
Our objective was to compare the effect of different exercise intensities on lipid oxidation in overweight men and women.
Nine young, healthy, overweight men and women were studied (age, 31.4 +/- 2.3 and 26.7 +/- 2.1 years; BMI, 27.9 +/- 0.4 and 27.2 +/- 0.5; for men and women, respectively). On one study day, the subjects first performed 30 minutes of cycling exercise at 30% of their maximal oxygen uptake (Vo(2max); E1 session), followed by 30 minutes of exercise at 50% Vo(2max) (E2 session). On a second study day, a similar E1 session was followed by 30 minutes of exercise at 70% Vo(2max) (E3 session). From the gas exchange measurements, the respiratory exchange ratio (RER) and the fat oxidation rate (FOR) were calculated. Plasma concentrations of glycerol and non-esterified fatty acids (NEFAs) were assayed.
RER was significantly lower for women during only the E1 session. For both sexes, RER decreased over time during the E2 and E3 sessions. During the E1 session, the FOR per kilogram of lean mass (LM) was higher among women, and it did not change over time despite an increase in plasma NEFAs. FOR per kilogram of LM was higher during the E2 exercise for both sexes. During E2 and E3 sessions, as the exercise time was prolonged, the FOR/kg LM increased simultaneously with the increase in the plasma glycerol.
Lipid oxidation during exercise is optimized for moderate and lengthy exercise. The enhancement of lipid oxidation occurring over time during moderate- and high-intensity exercises could be, in part, linked to the improvement of lipid mobilization. This fact is discussed to shed light on exercise modalities as a tool for the management of overweight.
我们的目的是比较不同运动强度对超重男性和女性脂质氧化的影响。
对9名年轻、健康的超重男性和女性进行了研究（年龄分别为31.4±2.3岁和26.7±2.1岁；体重指数分别为27.9±0.4和27.2±0.5）。在一个研究日，受试者首先以其最大摄氧量（Vo₂max）的30%进行30分钟的自行车运动（E1时段），随后以Vo₂max的50%进行30分钟的运动（E2时段）。在第二个研究日，进行类似的E1时段，随后以Vo₂max的70%进行30分钟的运动（E3时段）。通过气体交换测量，计算呼吸交换率（RER）和脂肪氧化率（FOR）。测定血浆甘油和非酯化脂肪酸（NEFA）的浓度。
仅在E1时段，女性的RER显著较低。对于两性，在E2和E3时段，RER随时间下降。在E1时段，每千克瘦体重（LM）的FOR在女性中较高，尽管血浆NEFA增加，但它并未随时间变化。两性在E2运动期间每千克LM的FOR较高。在E2和E3时段，随着运动时间延长，FOR/kg LM随着血浆甘油的增加而同时增加。
运动期间的脂质氧化在中等强度和长时间运动时最为优化。在中等强度和高强度运动过程中，随着时间推移脂质氧化的增强可能部分与脂质动员的改善有关。讨论这一事实是为了阐明运动方式作为超重管理工具的作用。
