Sommerer Claudia, Giannitsis Evangelos, Schwenger Vedat, Zeier Martin
Department of Nephrology, University Hospital of Heidelberg, Heidelberg, Germany.
Nephron Clin Pract. 2007;107(3):c77-81. doi: 10.1159/000108647. Epub 2007 Sep 21.
Cardiac biomarkers such as amino-terminal pro-B-type natriuretic peptide (NT-proBNP) and cardiac troponin T (cTNT) provide information on cardiovascular morbidity and mortality in patients with normal renal function. In a considerable number of chronic haemodialysis patients, both biomarkers - NT-proBNP and cTNT - are elevated despite the absence of cardiac ischaemia. The elevation of cardiac biomarkers in chronic haemodialysis patients is of prognostic value with respect to cardiovascular morbidity and mortality. They provide a useful rationale for the screening of occult cardiac disease and optimization of the dialysis procedure with respect to volume control.
心脏生物标志物，如氨基末端前B型利钠肽（NT-proBNP）和心肌肌钙蛋白T（cTNT），可为肾功能正常患者的心血管发病率和死亡率提供信息。在相当数量的慢性血液透析患者中，尽管没有心肌缺血，但NT-proBNP和cTNT这两种生物标志物均升高。慢性血液透析患者心脏生物标志物的升高对于心血管发病率和死亡率具有预后价值。它们为隐匿性心脏病的筛查以及透析程序在容量控制方面的优化提供了有用的理论依据。
