Hefer David Václav Fred, Munir Aman, Khouli Hassan
Cardiovascular Research Center, University of Vermont, College of Medicine, Burlington, Vermont, USA.
Blood Coagul Fibrinolysis. 2007 Oct;18(7):691-4. doi: 10.1097/MBC.0b013e3282a167a7.
The case of a 29 year-old man who suffered a cardiac arrest due to a massive pulmonary embolism while he was undergoing surgical repair of a complex tibial plateau fracture is presented. After 70 min of unsuccessful cardiopulmonary resuscitation a bolus of 20 mg tenecteplase was given, with a return of spontaneous circulation 2 min after administration of the drug. Pulmonary embolism was subsequently demonstrated on a pulmonary angiogram. To our knowledge this is the first report to show that the use of a low dose of tenecteplase might be useful to achieve the return of spontaneous circulation in the resuscitation of patients with cardiac arrest secondary to massive pulmonary embolism. Previously reported cases are reviewed.
本文介绍了一名29岁男性的病例，该患者在接受复杂胫骨平台骨折手术修复时，因大面积肺栓塞发生心脏骤停。在进行了70分钟的心肺复苏但未成功后，给予了20毫克替奈普酶推注，给药后2分钟恢复自主循环。随后在肺血管造影中证实了肺栓塞。据我们所知，这是第一份表明使用低剂量替奈普酶可能有助于使继发于大面积肺栓塞的心脏骤停患者复苏时恢复自主循环的报告。同时对先前报道的病例进行了回顾。
