卡马西平诱发的急性肉芽肿性间质性肾炎。

Carbamazepine-induced acute granulomatous interstitial nephritis.

作者信息

Hegarty J, Picton M, Agarwal G, Pramanik A, Kalra P A

机构信息

Department of Renal Medicine, Hope Hospital, Salford, UK.

出版信息

Clin Nephrol. 2002 Apr;57(4):310-3. doi: 10.5414/cnp57310.

DOI:10.5414/cnp57310

PMID:12005248

Abstract

A 79-year-old man, newly started on carbamazepine, presented with rash, eosinophilia and liver dysfunction progressing to acute renal failure despite discontinuation of the anti-epileptic agent. Percutaneous renal biopsy revealed acute granulomatous interstitial nephritis, which responded successfully to high-dose oral steroid therapy.

摘要

一名79岁男性，新开始服用卡马西平，出现皮疹、嗜酸性粒细胞增多和肝功能障碍，尽管停用了抗癫痫药物，但仍进展为急性肾衰竭。经皮肾活检显示为急性肉芽肿性间质性肾炎，高剂量口服类固醇治疗成功起效。