Garud Dinesh R, Ando Hiromune, Kawai Yumiko, Ishihara Hideharu, Koketsu Mamoru
Department of Chemistry, Faculty of Engineering, Gifu University, Gifu-501-1193, Japan.
Org Lett. 2007 Oct 25;9(22):4455-8. doi: 10.1021/ol701761t. Epub 2007 Sep 25.
Selenapenams, selenacephems, and selenazepines were synthesized using a 2-(trimethylsilyl)ethyl (TSE) protection approach in an extremely simple way. TSE protection for selenium is used for the first time in the synthesis of selenium-containing beta-lactam. Novel intramolecular cycloaddition reaction of selenium with alkynes and allenes is used in the present synthesis.
