一个黄嘌呤尿症家族——先证者具有免疫反应性黄嘌呤氧化酶但无黄嘌呤氧化酶活性。
A xanthinuric family--the proposita having immunologically reactive xanthine oxidase but no xanthine oxidase activity.
作者信息
Yamamoto T, Moriwaki Y, Takahashi S, Hada T, Suda M, Imanishi H, Agbedana O E, Nanahoshi M, Higashino K
机构信息
Third Department of Internal Medicine, Hyogo College of Medicine, Japan.
出版信息
Adv Exp Med Biol. 1991;309A:369-72. doi: 10.1007/978-1-4899-2638-8_84.
PMID:1789246
Abstract
The antibody was raised against purified human liver xanthine oxidase in a rabbit. In a xanthinuric patient, the double immunodiffusion method demonstrated the existence of an immunologically reactive duodenal mucosa xanthine oxidase which did not possess xanthine oxidase activity. These results indicated that xanthine oxidase protein is abnormal in structure and/or amino acid sequence.
摘要
该抗体是通过用纯化的人肝脏黄嘌呤氧化酶免疫家兔制备的。在一名黄嘌呤尿症患者中，双向免疫扩散法显示存在一种无黄嘌呤氧化酶活性但具有免疫反应性的十二指肠黏膜黄嘌呤氧化酶。这些结果表明，黄嘌呤氧化酶蛋白在结构和/或氨基酸序列上存在异常。
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