Simmonds H A, Stutchbury J H, Webster D R, Spencer R E, Fisher R A, Wooder M, Buckley B M
J Inherit Metab Dis. 1984;7(2):77-9. doi: 10.1007/BF01805810.
This paper reports biochemical studies in a pregnant xanthinuric female (McKusick 27830) and compares the results with findings in three other xanthinurics studied by us, including a previously unreported female who had a nephrectomy for xanthine stones. The findings of raised levels of uric acid in plasma and urine at presentation in the third trimester of pregnancy, and the subsequent fall to almost undetectable levels 6 weeks post-partum, is regarded as evidence of the extent of fetal uric acid production and clearance by the maternal circulation.
本文报道了对一名患有黄嘌呤尿症的孕妇（麦库西克27830）的生化研究，并将结果与我们研究的其他三名黄嘌呤尿症患者的发现进行了比较，其中包括一名此前未报道过的因黄嘌呤结石接受肾切除术的女性。在妊娠晚期就诊时血浆和尿液中尿酸水平升高，产后6周随后降至几乎检测不到的水平，这一发现被视为胎儿尿酸产生和经母体循环清除程度的证据。
