Rosenberg S, Silverstein H, Flanzer J, Wanamaker H
Department of Otorhinolaryngology, University of Pennsylvania, Philadelphia.
Am J Otol. 1991 Sep;12(5):336-40.
In patients with Menière's disease, the possibility of developing Menière's disease in the uninvolved ear is of great concern. In this study, the incidence of bilateral Menière's disease (BMD) in medically treated patients was found to be 17 percent, while in surgically treated patients it was significantly lower, 5.9 percent (p less than 0.01). The incidence of BMD for each surgical procedure was as follows: 9 percent after endolymphatic subarachnoid shunt (n = 101), 7 percent after cochleovestibular neurectomy (n = 100), 6 percent after cochleosacculotomy (n = 18), and 0 percent after vestibular nerve section (n = 73). The average duration of disease prior to surgery was 6.3 years. Seventy-two percent of the patients who developed BMD did so within 5 years of the onset of their symptoms. Proper patient selection is the most likely explanation for the low incidence of BMD among surgically treated patients.
在梅尼埃病患者中,未受累耳发生梅尼埃病的可能性备受关注。在本研究中,接受药物治疗的患者双侧梅尼埃病(BMD)的发生率为17%,而接受手术治疗的患者发生率显著较低,为5.9%(p<0.01)。每种手术方法的BMD发生率如下:内淋巴蛛网膜下腔分流术后为9%(n=101),耳蜗前庭神经切断术后为7%(n=100),耳蜗球囊切开术后为6%(n=18),前庭神经切断术后为0%(n=73)。手术前疾病的平均持续时间为6.3年。发生BMD的患者中有72%是在症状出现后的5年内发病。恰当的患者选择最有可能解释手术治疗患者中BMD发生率较低的原因。