准分子激光原位角膜磨镶术后与链格孢属相关的上皮树枝状缺损
Post-LASIK epithelial dendritic defect associated with Alternaria.
作者信息
Kocatürk Tolga, Pineda Roberto, Green Laura K, Azar Dimitri T
机构信息
Department of Ophthalmology, Adnan Menderes University Medical School, Aydin, Turkey.
出版信息
Cornea. 2007 Oct;26(9):1144-6. doi: 10.1097/ICO.0b013e31812dfad1.
PURPOSE
To report a case of a dendritic epithelial defect with interface inflammation associated with Alternaria sp. after laser in situ keratomileusis (LASIK) surgery.
METHODS
A case report of a 46-year-old woman who presented with a dendritic epithelial defect and interface inflammation after LASIK surgery.
RESULTS
After an apparent post-LASIK herpes simplex keratitis with related interface inflammation failed to respond to medical therapy, cornea culture results were positive for Alternaria fungal sp. 2 weeks and 6 days after presentation. Viral cultures and polymerase chain reaction were negative for herpes simplex virus. Six months after penetrating keratoplasty (and 1 year after LASIK), the patient underwent a cataract extraction OD. Best-corrected visual acuity 18 months after the original LASIK procedure was 20/25 OD.
CONCLUSIONS
Alternaria keratitis may present with a dendritic epithelial defect with interface inflammation mimicking herpes simplex virus.
目的
报告1例准分子原位角膜磨镶术（LASIK）后出现与链格孢属相关的树枝状上皮缺损伴界面炎症的病例。
方法
1例46岁女性患者LASIK术后出现树枝状上皮缺损和界面炎症的病例报告。
结果
LASIK术后出现明显的单纯疱疹性角膜炎伴相关界面炎症，药物治疗无效，就诊2周零6天后角膜培养结果显示链格孢属真菌阳性。单纯疱疹病毒的病毒培养和聚合酶链反应均为阴性。穿透性角膜移植术后6个月（LASIK术后1年），患者右眼行白内障摘除术。初次LASIK手术18个月后的最佳矫正视力为右眼20/25。
结论
链格孢属角膜炎可能表现为类似单纯疱疹病毒感染的树枝状上皮缺损伴界面炎症。
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