淋巴结中的成纤维网状细胞调节初始T细胞的稳态。

Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells.

作者信息

Link Alexander, Vogt Tobias K, Favre Stéphanie, Britschgi Mirjam R, Acha-Orbea Hans, Hinz Boris, Cyster Jason G, Luther Sanjiv A

机构信息

Department of Biochemistry, University of Lausanne, 1066 Epalinges, Switzerland.

出版信息

Nat Immunol. 2007 Nov;8(11):1255-65. doi: 10.1038/ni1513. Epub 2007 Sep 23.

DOI:10.1038/ni1513

PMID:17893676

Abstract

Interleukin 7 is essential for the survival of naive T lymphocytes. Despite its importance, its cellular source in the periphery remains poorly defined. Here we report a critical function for lymph node access in T cell homeostasis and identify T zone fibroblastic reticular cells in these organs as the main source of interleukin 7. In vitro, T zone fibroblastic reticular cells were able to prevent the death of naive T lymphocytes but not of B lymphocytes by secreting interleukin 7 and the CCR7 ligand CCL19. Using gene-targeted mice, we demonstrate a nonredundant function for CCL19 in T cell homeostasis. Our data suggest that lymph nodes and T zone fibroblastic reticular cells have a key function in naive CD4(+) and CD8(+) T cell homeostasis by providing a limited reservoir of survival factors.

摘要

白细胞介素7对初始T淋巴细胞的存活至关重要。尽管其重要性，但它在外周的细胞来源仍不清楚。在此我们报告了淋巴结进入在T细胞稳态中的关键作用，并确定这些器官中的T区成纤维网状细胞是白细胞介素7的主要来源。在体外，T区成纤维网状细胞能够通过分泌白细胞介素7和CCR7配体CCL19来防止初始T淋巴细胞而非B淋巴细胞的死亡。利用基因靶向小鼠，我们证明了CCL19在T细胞稳态中具有不可替代的功能。我们的数据表明，淋巴结和T区成纤维网状细胞通过提供有限的存活因子储备，在初始CD4(+)和CD8(+) T细胞稳态中发挥关键作用。