Rivera-Perez Jaime A
Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA.
J Cell Physiol. 2007 Dec;213(3):654-60. doi: 10.1002/jcp.21292.
The definitive axes of the mouse embryo can be unequivocally identified in embryos dissected at 5.5 days of gestation. However, how and when are these axes established remains an open question. At pre-implantation stages, different approaches have been aimed at determining if events occurring in the zygote influence the geometrical arrangement of the blastocyst. An intense debate has focused on whether the mouse embryo is a pre-patterned or a regulative structure. At post-implantation stages, the efforts have been concentrated in understanding how extra-embryonic tissues affect the formation of the primitive streak, the caudal marker of the anteroposterior axis. Here I summarize the last 10 years of research in this field.
小鼠胚胎的确定轴可以在妊娠5.5天时解剖的胚胎中明确识别。然而，这些轴是如何以及何时建立的仍然是一个悬而未决的问题。在植入前阶段，不同的方法旨在确定合子中发生的事件是否会影响囊胚的几何排列。一场激烈的争论集中在小鼠胚胎是预模式化结构还是调节性结构上。在植入后阶段，研究工作集中在理解胚外组织如何影响原条的形成，原条是前后轴的尾端标记。在此，我总结了该领域过去十年的研究情况。
