von Landenberg Philipp, Döring Yvonne, Modrow Susanne, Lackner Karl J
Lnstitut für Klinische Chemie und Laboratoriumsmedizin, Johannes Gutenberg Universität Mainz, Mainz, Germany.
Ann N Y Acad Sci. 2007 Jun;1108:578-83. doi: 10.1196/annals.1422.060.
Antiphospholipid antibodies show a close association to a variety of infections. Recent data implicate that parvovirus B19 may be used as a model-system for studying the interaction of viral infection and the development of these autoantibodies. B19-related diseases commonly associated with the acute infection show flu-like symptoms, transient arthralgias, leukopenia and thrombocytopenia, and, in pregnant women, spontaneous abortion and hydrops fetalis. Hepatitis, myocarditis, meningitis, encephalitis, as well as pure red cell anemia may occur occasionally. In addition, parvovirus B19 infections have been frequently described as the cause or trigger of various forms of autoimmune diseases affecting all blood cell lines, joints, connective tissue, uvea, and large and small vessels. Molecular mimicry may be one major contribution to the appearance of autoimmune antibodies, for example, antiphospholipid and antineutrophil cytoplasmic antibodies as well as antinuclear antigens. These mechanisms implicated in the pathogenesis of parvovirus B19-triggered autoimmune diseases, especially focused on the development of antiphospholipid antibodies, will be discussed in this mini review.
抗磷脂抗体与多种感染密切相关。最近的数据表明，细小病毒B19可作为研究病毒感染与这些自身抗体产生之间相互作用的模型系统。与急性感染常见相关的B19相关疾病表现为流感样症状、短暂性关节痛、白细胞减少和血小板减少，在孕妇中还会出现自然流产和胎儿水肿。肝炎、心肌炎、脑膜炎、脑炎以及纯红细胞贫血偶尔也会发生。此外，细小病毒B19感染经常被描述为影响所有血细胞系、关节、结缔组织、葡萄膜以及大小血管的各种自身免疫性疾病的病因或触发因素。分子模拟可能是自身免疫抗体出现的一个主要原因，例如抗磷脂抗体、抗中性粒细胞胞浆抗体以及抗核抗原。本综述将讨论这些与细小病毒B19引发的自身免疫性疾病发病机制相关的机制，尤其关注抗磷脂抗体的产生。
