Jarvik L F, Yen F S, Dahlberg C C, Fleiss J L, Jaffe J, Kato T, Moralishvili E
Department of Medical Genetics, New York State Psychiatric Institute, USA.
Dis Nerv Syst. 1974 Sep;35(9):399-407.
The results of the present study demonstrate once again that, on the average, the addition of LSD in vitro leads to chromosome damage in excess of that observed in cultures without such added LSD even though nearly all of the in vitro experiments were carried out on blood cultures derived from patients who had already been started on the drug regime in vivo. By contrast, the present data provide no evidence for a measurable detrimental effect of LSD and DA when administered to patients under medical supervision. It is conceivable that an effect might have emerged had we been able to monitor chromosomes separately before and after administration of LSD and before and after administation of DA, but we consider it unlikely that either drug would exert protective action against potentially damaging consequences of the other. It is conceivable also that damaged cells are sequestered to give rise eventually to neoplasia-prone clones. The likelihood of that possibility can be determined only by long-term follow-up studies.
本研究结果再次表明，平均而言，体外添加麦角酸二乙酰胺（LSD）会导致染色体损伤，其程度超过未添加LSD的培养物中观察到的损伤，尽管几乎所有体外实验都是在体内已开始药物治疗方案的患者的血液培养物上进行的。相比之下，目前的数据没有提供证据表明在医学监督下给患者使用LSD和二乙胺（DA）会产生可测量的有害影响。可以想象，如果我们能够在给予LSD之前和之后以及给予DA之前和之后分别监测染色体，可能会出现一种效应，但我们认为这两种药物都不太可能对另一种药物的潜在破坏性后果起到保护作用。也可以想象，受损细胞会被隔离，最终产生易发生肿瘤的克隆。只有通过长期随访研究才能确定这种可能性的大小。
