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Mutagenicity testing of 3 hallucinogens: LSD, psilocybin and delta 9-THC, using the micronucleus test.

作者信息

Van Went G F

出版信息

Experientia. 1978 Mar 15;34(3):324-5. doi: 10.1007/BF01923013.

DOI:10.1007/BF01923013
PMID:631257
Abstract

Using the micronucleus test as a screening method for mutagenic activity, no significant increase in the number of micronuclei was found when LSD, psilocybin or delta 9-THC were administered in 3 logarithmically increasing doses to mice, Azathioiprine (Imuran), given as a positive control, caused a statistically significantt increase in the micronucleated cells.

摘要

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本文引用的文献

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Dis Nerv Syst. 1974 Sep;35(9):399-407.
2
Marihuana: the grass may no longer be greener.大麻：这棵草可能不再那么绿了。
Science. 1974 Aug 23;185(4152):683-5. doi: 10.1126/science.185.4152.683.
3
[Chemical mutagenesis in mammals. The Chinese hamster bone marrow as an in vivo test system. Hematological findings after treatment with trenimon].[哺乳动物中的化学诱变。中国仓鼠骨髓作为一种体内测试系统。用三胺硫磷治疗后的血液学发现]
大麻对单一使用者的遗传毒性。
Front Psychiatry. 2021 Dec 6;12:753562. doi: 10.3389/fpsyt.2021.753562. eCollection 2021.
4
Canadian Cannabis Consumption and Patterns of Congenital Anomalies: An Ecological Geospatial Analysis.加拿大的大麻消费与先天畸形模式：生态地理空间分析。
J Addict Med. 2020 Sep/Oct;14(5):e195-e210. doi: 10.1097/ADM.0000000000000638.
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Cannabis Consumption Patterns Explain the East-West Gradient in Canadian Neural Tube Defect Incidence: An Ecological Study.大麻消费模式解释了加拿大神经管缺陷发病率的东西方梯度差异：一项生态学研究。
Glob Pediatr Health. 2019 Dec 11;6:2333794X19894798. doi: 10.1177/2333794X19894798. eCollection 2019.
6
Impacts of cannabinoid epigenetics on human development: reflections on Murphy et. al. 'cannabinoid exposure and altered DNA methylation in rat and human sperm' epigenetics 2018; 13: 1208-1221.大麻素表观遗传学对人类发育的影响：对 Murphy 等人的思考。'大麻素暴露与大鼠和人精子中 DNA 甲基化的改变'表观遗传学 2018; 13: 1208-1221。
Epigenetics. 2019 Nov;14(11):1041-1056. doi: 10.1080/15592294.2019.1633868. Epub 2019 Jul 11.
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Low doses of widely consumed cannabinoids (cannabidiol and cannabidivarin) cause DNA damage and chromosomal aberrations in human-derived cells.低剂量的广泛消费的大麻素（大麻二酚和大麻二酚酸）会导致人类来源的细胞中的 DNA 损伤和染色体畸变。
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Neuropharmacology. 2018 Nov;142:143-166. doi: 10.1016/j.neuropharm.2018.05.012. Epub 2018 Jun 5.
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