Khurana R, Post J C, Kalyanaraman K
Department of Neurology, State University of New York at Buffalo, School of Medicine and E. J. Meyer Memorial Hospital, Buffalo, USA.
Dis Nerv Syst. 1974 Mar;35(3):135-7.
A 47-year-old chronic alcoholic with acute onset of spastic bulbar paralysis and quadriparesis with recovery has been reported. The differential diagnosis of occurrence of bulbar symptoms in an alcoholic has been discussed. It is postulated that on anatomical and clinical grounds this case probably represents the occurrence of central pontine myelinolysis with recovery. Attention has been drawn to recent literature in which the importance of vascular insufficiency, hypotension and disturbance of fluid and electrolyte balance in the occurrence of irreversible myelinolytic lesions has been stressed. It is postulated that the recovery of this patient from a seemingly inexorably progressive lesion was the result of prompt reversal of etiologic factors which result in central pontine myelinolysis-like, fluid and electrolyte imbalance, hypotension and vascular insufficiency.
据报道,一名47岁的慢性酒精中毒患者急性起病,出现痉挛性延髓麻痹和四肢瘫,随后恢复。文中讨论了酒精中毒患者出现延髓症状的鉴别诊断。据推测,基于解剖学和临床依据,该病例可能代表了伴有恢复的中央桥脑髓鞘溶解症。有人指出了近期的文献,其中强调了血管供血不足、低血压以及液体和电解质平衡紊乱在不可逆髓鞘溶解病变发生中的重要性。据推测,该患者从看似不可阻挡的进行性病变中恢复,是导致类似中央桥脑髓鞘溶解症的病因因素(液体和电解质失衡、低血压和血管供血不足)迅速逆转的结果。