Cordell Rebecca L, Willis Kerry A, Wyche Kevin P, Blake Robert S, Ellis Andrew M, Monks Paul S
Department of Chemistry, University of Leicester, Leicester, UK.
Anal Chem. 2007 Nov 1;79(21):8359-66. doi: 10.1021/ac071193c. Epub 2007 Sep 26.
Chemical ionization reaction time-of-flight mass spectrometry (CIR-TOF-MS) has been used for the analysis of prepared mixtures of chemical weapon agents (CWAs) sarin and sulfur mustard. Detection of the CWA simulants 2-chloroethyl ethyl sulfide, triethyl phosphate, and dimethyl methyl phosphonate has also been investigated. Chemical ionization of all the agents and simulants was shown to be possible using the CIR-TOF-MS technique with a variety of reagent ions, and the sensitivity was optimized by variation of instrument parameters. The ionization process was found to be largely unaffected by sample humidity levels, demonstrating the potential suitability of the method to a range of environmental conditions, including the analysis of CWAs in air and in the breath of exposed individuals.
化学电离反应飞行时间质谱法（CIR-TOF-MS）已用于分析化学战剂（CWA）沙林和芥子气的制备混合物。还研究了对化学战剂模拟物2-氯乙基乙基硫醚、磷酸三乙酯和甲基膦酸二甲酯的检测。结果表明，使用CIR-TOF-MS技术并搭配多种试剂离子，所有战剂和模拟物都可以实现化学电离，并且通过改变仪器参数优化了灵敏度。研究发现，电离过程在很大程度上不受样品湿度水平的影响，这表明该方法有可能适用于一系列环境条件，包括分析空气中的化学战剂以及暴露个体呼出气体中的化学战剂。
