Grieve R B, Frank G R, Stewart V A, Parsons J C, Belasco D L, Hepler D I
Department of Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins 80523.
Am J Vet Res. 1991 Dec;52(12):2040-2.
Three studies were conducted to determine the efficacy of milbemycin oxime in the prevention of Dirofilaria immitis infection in dogs. Dogs were given single or multiple experimental inoculations with infective third-stage D immitis larvae and were treated with milbemycin oxime at a target dosage of 0.5 mg/kg of body weight either once or at monthly intervals at various times after inoculation. The compound was effective in preventing infection when 1 dose was administered 30 or 45 days after inoculation. Significant, but incomplete, protection was achieved when single treatments were administered 60 or 90 days after inoculation. Multiple monthly treatments beginning 60 days after inoculation appeared to provide additive effects that resulted in restoration of complete efficacy.
进行了三项研究以确定米尔贝肟预防犬心丝虫感染的效果。给犬单次或多次接种感染性第三期犬恶丝虫幼虫，并在接种后的不同时间，以0.5毫克/千克体重的目标剂量，对犬进行单次或每月一次的米尔贝肟治疗。接种后30天或45天给予一剂该化合物可有效预防感染。接种后60天或90天进行单次治疗可获得显著但不完全的保护。接种后60天开始每月多次治疗似乎具有累加效应，从而恢复了完全疗效。
