Tagawa M, Okano S, Hayashi Y, Kusano K
Division of Veterinary Surgery, Nippon Veterinary and Animal Science University, Tokyo, Japan.
J Vet Med Sci. 1993 Aug;55(4):693-4. doi: 10.1292/jvms.55.693.
To examine the prophylactic efficacy of milbemycin oxime against Dirofilaria immitis infection, 42 filaria-free beagles were inoculated with 100 infective larvae of the parasite. Milbemycin oxime was administered orally at doses of 0.05 to 1.0 mg/kg body weight one month after inoculation, and at a single dose of 0.25 mg/kg body weight on days 1 to 90 after inoculation. All dogs were euthanized and autopsied to evaluate the prophylactic effect of the drug against D. immitis infection 6 months after inoculation. It was confirmed that a dose of 0.25 mg/kg of milbemycin oxime completely-protected the infection 15 to 60 days after infection.
