Gavi Shai, Feiner Joshua J, Melendez Mark M, Mynarcik Dennis C, Gelato Marie C, McNurlan Margaret A
Department of Medicine, Division of General Medicine and Geriatrics, School of Medicine, Health Sciences Center, State University of New York at Stony Brook, Stony Brook, NY 11794-8154, USA.
J Gerontol A Biol Sci Med Sci. 2007 Sep;62(9):997-1001. doi: 10.1093/gerona/62.9.997.
Similar to lipodystrophy syndromes, aging results in increased visceral adiposity with loss of subcutaneous adipose tissue in the extremities. The hypothesis of this study is that the distribution of limb fat to trunk fat (LF/TF) ratio in elderly persons has a stronger correlation than trunk fat alone to insulin resistance and adiponectin levels.
Thirty-eight elderly participants were divided into an insulin-resistant (IR) group and an insulin-sensitive (IS) group. Limb fat and trunk fat were measured by dual-energy x-ray absorptiometry. Insulin resistance was measured by a hyperinsulinemic-euglycemic clamp.
There was no significant difference between the IS and IR groups with respect to body mass index, body fat index, absolute amount of trunk fat, or percent body fat. However, the difference in LF/TF ratio between the IS (1.02 +/- 0.05) and the IR groups (0.77 +/- 0.05) was highly significantly different (p <.001). Insulin resistance had a stronger correlation to the LF/TF ratio (r = 0.61, p <.001) than to absolute trunk fat (r = -0.32, p =.051). Adiponectin levels had a strong association with the LF/TF ratio (r = 0.63, p <.001), but did not correlate to absolute trunk fat (r = -0.24, p =.18).
The distribution of body fat (LF/TF ratio) in elderly persons is a stronger determinant of insulin resistance and adiponectin levels than is trunk fat alone. The LF/TF ratio can be a useful tool to assess insulin sensitivity in the elderly population.
与脂肪营养不良综合征相似，衰老会导致内脏脂肪增多，同时四肢皮下脂肪组织减少。本研究的假设是，老年人肢体脂肪与躯干脂肪的比例（LF/TF）相较于单纯的躯干脂肪，与胰岛素抵抗及脂联素水平的相关性更强。
38名老年参与者被分为胰岛素抵抗（IR）组和胰岛素敏感（IS）组。通过双能X线吸收法测量肢体脂肪和躯干脂肪。采用高胰岛素-正葡萄糖钳夹技术测量胰岛素抵抗。
IS组和IR组在体重指数、体脂指数、躯干脂肪绝对量或体脂百分比方面无显著差异。然而，IS组（1.02±0.05）与IR组（0.77±0.05）的LF/TF比值差异高度显著（p<.001）。胰岛素抵抗与LF/TF比值的相关性（r = 0.61，p<.001）强于与躯干脂肪绝对量的相关性（r = -0.32，p =.051）。脂联素水平与LF/TF比值密切相关（r = 0.63，p<.001），但与躯干脂肪绝对量无相关性（r = -0.24，p =.18）。
老年人身体脂肪的分布（LF/TF比值）比单纯的躯干脂肪更能决定胰岛素抵抗和脂联素水平。LF/TF比值可作为评估老年人群胰岛素敏感性的有用工具。
