Louw Susan, Jacobson Barry F, Büller Harry
Department of Molecular Medicine and Haematology, University of Witwatersrand.
Clin Appl Thromb Hemost. 2008 Jul;14(3):352-5. doi: 10.1177/1076029607304411. Epub 2007 Sep 25.
Abnormalities that predispose to a hypercoagulable state with an increased incidence of venous thrombosis have been described in human immunodeficiency virus (HIV) infections and are associated with an increased mortality. A recent systematic review by Klein et al concluded that further studies are essential to elucidate the link between HIV infection and deep vein thrombosis (DVT). We prospectively evaluated 24 consecutive, active people presenting with an acute DVT; 13 consented to HIV testing, revealing an HIV prevalence of 84% (95% confidence interval [CI], 0.65-1.04). In a matched healthy control group, the HIV prevalence was 4% (95% CI, 0.039-0.041). The high HIV prevalence in the DVT group that consented to testing was also significantly higher compared to that in the South African population, estimated to be 10% in 2005. Although the study numbers were low, a statistically significant increased prevalence of HIV infection was found in patients with acute DVTs.
在人类免疫缺陷病毒（HIV）感染中，已发现一些异常情况会导致血液高凝状态，静脉血栓形成的发生率增加，且与死亡率升高相关。Klein等人最近的一项系统评价得出结论，进一步的研究对于阐明HIV感染与深静脉血栓形成（DVT）之间的联系至关重要。我们对24例连续的急性DVT患者进行了前瞻性评估；13例同意进行HIV检测，HIV感染率为84%（95%置信区间[CI]，0.65 - 1.04）。在匹配的健康对照组中，HIV感染率为4%（95%CI，0.039 - 0.041）。同意检测的DVT组中的高HIV感染率也显著高于南非人群（2005年估计为10%）。尽管研究样本数量较少，但在急性DVT患者中发现HIV感染率有统计学意义的显著增加。
