前体mRNA可变剪接的神经元调控
Neuronal regulation of alternative pre-mRNA splicing.
作者信息
Li Qin, Lee Ji-Ann, Black Douglas L
机构信息
Howard Hughes Medical Institute, University of California, Los Angeles, 6-762 MacDonald Research Laboratories, 675 Charles E. Young Drive South, Los Angeles, California 90095, USA.
出版信息
Nat Rev Neurosci. 2007 Nov;8(11):819-31. doi: 10.1038/nrn2237.
Alternative pre-mRNA splicing has an important role in the control of neuronal gene expression. Many neuronal proteins are structurally diversified through the differential inclusion and exclusion of sequences in the final spliced mRNA. Here, we discuss common mechanisms of splicing regulation and provide examples of how alternative splicing has important roles in neuronal development and mature neuron function. Finally, we describe regulatory proteins that control the splicing of some neuronally expressed transcripts.
可变前体mRNA剪接在神经元基因表达调控中发挥着重要作用。许多神经元蛋白通过最终剪接的mRNA中序列的差异包含和排除而在结构上具有多样性。在这里，我们讨论剪接调控的常见机制，并举例说明可变剪接在神经元发育和成熟神经元功能中的重要作用。最后，我们描述了控制一些神经元表达转录本剪接的调控蛋白。
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