Tang Haiying, Wu Ed X, Kennan Richard, Liu Haiying, Williams Donald S
Department of Imaging, Merck Research Laboratories, Rahway, New Jersey, USA.
J Magn Reson Imaging. 2007 Oct;26(4):1064-70. doi: 10.1002/jmri.21055.
To implement and evaluate the gradient reversal-based chemical shift imaging technique to obtain qualitative and quantitative spatially-registered fat and water images with high imaging efficiency at very high field.
A multiecho gradient reversal-based sequence allowing interleaved water-fat imaging during a single acquisition and quantitation of fat/water content is presented. The sequence was optimized and implemented at 11.7T. The quantitation was verified with water-fat phantoms and applied to lipid measurement in an in vivo mouse model.
Results from phantoms, in vivo lipid measurement in mouse liver and hind limb muscle, and ex vivo rat knee imaging experiments demonstrated the robustness and high selectivity of this technique for interleaved and quantitative water and fat imaging at very high field.
The proposed MRI technique permits interleaved water and fat imaging, with which spectrally well-separated water and fat images at the identical slice locations could be obtained in a single acquisition without increasing scan time. The technique could be used for in vivo quantitative mapping of lipid content and applied to investigations using small animal experiment models.
应用并评估基于梯度反转的化学位移成像技术，以在超高场强下高效成像，获取定性和定量的空间配准脂肪和水图像。
提出一种基于多回波梯度反转的序列，该序列允许在单次采集中进行水脂交错成像并定量脂肪/水含量。该序列在11.7T场强下进行了优化和实现。通过水脂模型验证了定量方法，并将其应用于活体小鼠模型的脂质测量。
模型实验、小鼠肝脏和后肢肌肉的活体脂质测量以及离体大鼠膝关节成像实验的结果表明，该技术在超高场强下进行水脂交错和定量成像具有稳健性和高选择性。
所提出的磁共振成像技术允许进行水脂交错成像，通过该技术可在不增加扫描时间的情况下，在单次采集中获得相同层面位置上频谱分离良好的水和脂肪图像。该技术可用于脂质含量的活体定量成像，并应用于小动物实验模型的研究。
