牙龈卟啉单胞菌脂多糖对人牙周膜成纤维细胞胶原吞噬作用的影响
[Effects of Porphyromonas gingivalis lipopolysaccharide on collagen phagocytosis by human periodontal ligament fibroblasts].
作者信息
Fang Chang-yun, Su Zheng, Chen Lei, Fan Ming-wen, Jian Xin-chun, Chen Zhi
机构信息
Stomatological Department, Xiangya Hospital of Central South University, Changsha 410008, China.
出版信息
Hua Xi Kou Qiang Yi Xue Za Zhi. 2007 Aug;25(4):339-41.
OBJECTIVE
To investigate the effects of Porphyromonas gingivalis (P. gingivalis) lipopolysaccharide (LPS) on collagen phagocytosis of human periodontal ligament fibroblasts (hPDLF).
METHODS
Fluorescence localization and flow cytometry was used to test the collagen phygocytosis of hPDLF stimulated by the various concentration of LPS for 48 hours in vitro.
RESULTS
The collagen phygocytosis of hPDLF was increased significantly by 0.1 microg/mL LPS (P < 0.05).
CONCLUSION
This study indicates that P. gingivalis LPS may enhance the degradation of collagen by stimulating the phagocytic activity of the hPDLF in periodontitis.
目的
研究牙龈卟啉单胞菌（P. gingivalis）脂多糖（LPS）对人牙周膜成纤维细胞（hPDLF）胶原吞噬作用的影响。
方法
采用荧光定位和流式细胞术检测体外经不同浓度LPS刺激48小时的hPDLF的胶原吞噬作用。
结果
0.1μg/mL LPS可显著增加hPDLF的胶原吞噬作用（P < 0.05）。
结论
本研究表明，牙龈卟啉单胞菌LPS可能通过刺激牙周炎中hPDLF的吞噬活性来增强胶原降解。
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