Wan Kuo, Jing Quan, Zhao Ji-zhi
Painless Dental Treatment Center, Peking Union Medical College Hospital, Beijing 100730, China.
Hua Xi Kou Qiang Yi Xue Za Zhi. 2007 Aug;25(4):365-7, 374.
To evaluate the sedative effect of continuous intravenous infusion of midazolam in treating severe dental phobia.
31 patients with severe dental phobia were enrolled and all of them had good communication with dentists. Two teeth in each patient were assigned to control group and experiment group seperately. The control group received root canal therapy. The experiment group were sedated by intravenous midazolam and received root canal therapy. The treat dependence and behavior therapy efficacy were evaluated. The vital signs and side effects during treatment were noted.
Continuous intravenous infusion of midazolam showed a significant good sedative effect on patients with severe dental phobia. There were statistical difference in the Houpt score and the Frankl score between experiment group and control group (z = -4.846, P = 0.000; z = -4.907, P = 0.000). The total dose of midazolam was (9.58 +/- 3.76) mg, and mean infusion rate was (0.28 +/- 0.06) mg x kg(-1) x h(-1). The blood pressure, heart rate and respiration of experiment group were depressed. But these changes didn't interfere with the completion of the whole treatment. No severe side effects were detected.
The single use of midazolam as an intravenous sedation agent has satisfactory effect on patients with severe dental phobia.
评估持续静脉输注咪达唑仑治疗重度牙科恐惧症的镇静效果。
纳入31例重度牙科恐惧症患者，所有患者均能与牙医良好沟通。将每位患者的两颗牙齿分别分配至对照组和试验组。对照组接受根管治疗。试验组静脉注射咪达唑仑镇静后接受根管治疗。评估治疗依从性和行为治疗效果。记录治疗期间的生命体征和副作用。
持续静脉输注咪达唑仑对重度牙科恐惧症患者显示出显著的良好镇静效果。试验组和对照组在Houpt评分和Frankl评分上存在统计学差异（z = -4.846，P = 0.000；z = -4.907，P = 0.000）。咪达唑仑总剂量为（9.58±3.76）mg，平均输注速率为（0.28±0.06）mg·kg⁻¹·h⁻¹。试验组患者的血压、心率和呼吸受到抑制。但这些变化并未干扰整个治疗的完成。未检测到严重副作用。
单用咪达唑仑作为静脉镇静剂对重度牙科恐惧症患者有满意疗效。
