Li Peng-wang, Wang Yu-jin, Liu Jun-fang
School of Forensic Medicine, Shanxi Medical University, Taiyuan 030001, China.
Fa Yi Xue Za Zhi. 2007 Aug;23(4):309-11, 315.
Saliva is an easily collected body fluid and has simple composition. Some drugs concentrations in saliva can reflect their blood level. This paper analyzes the mechanisms of drug transfer from blood into saliva and the influencing factors, reviews the methods of sample collection, preparation, analysis of the abused drugs in saliva, and the relationship between abused drugs content in saliva and in blood. We believe that saliva is a valuable sample in clinic and forensic medicine. It is important in forensic science field to estimate abused drugs concentrations in blood by via their saliva concentrations.
唾液是一种易于采集的体液,成分简单。唾液中某些药物的浓度可以反映其血液水平。本文分析了药物从血液转移到唾液的机制及影响因素,综述了唾液中滥用药物的样本采集、制备、分析方法,以及唾液与血液中滥用药物含量的关系。我们认为唾液是临床和法医学中有价值的样本。通过唾液浓度估算血液中滥用药物的浓度在法医学领域很重要。