Filip Rafał S, Pierzynowski Stefan G, Lindegard Birger, Wernerman Jan, Haratym-Maj Agnieszka, Podgurniak Małgorzata
Department of Bone Metabolic Diseases, Institute of Agricultural Medicine, Jaczewskiego 2, 20-950 Lublin, Poland.
Int J Vitam Nutr Res. 2007 Mar;77(2):89-97. doi: 10.1024/0300-9831.77.2.89.
Several studies have shown that alpha-ketoglutaric acid (AKG) increases serum levels of proline and has beneficial effects on skeletal development. We studied the effect of alpha-ketoglutaric (AKG) acid calcium salt (6 g AKG and 1.68 Ca/day) or calcium alone (1.68 Ca/day) on serum C-terminal cross-linked telopeptide of type I collagen (CTX) and osteocalcin (OC), as well as on lumbar spine bone mineral density (BMD) in a randomized, parallel group, double-blind, 6-month study conducted on 76 postmenopausal women with osteopenia. The maximum decrease of the mean CTX level in the AKG-Ca group was observed after 24 weeks (37.0%, p = 0.006). The differences in CTX between study groups were statistically significant after 12 and 24 weeks. The OC serum level was not affected by treatments. The BMD of the AKG-Ca group increased by 1.6% from baseline; however, the difference between treatment groups was estimated as 0.9% (non-significant). This study suggests the potential usefulness of AKG-Ca in osteopenic postmenopausal women. AKG-Ca induced beneficial changes in serum CTX, which was consistent with preserving the bone mass in the lumbar spine; however, the long-term effect needs to be further investigated.
多项研究表明，α-酮戊二酸（AKG）可提高血清脯氨酸水平，并对骨骼发育具有有益作用。我们在一项针对76名患有骨质减少的绝经后女性进行的随机、平行组、双盲、为期6个月的研究中，研究了α-酮戊二酸（AKG）钙盐（每天6克AKG和1.68克钙）或单独补钙（每天1.68克钙）对血清I型胶原C端交联肽（CTX）和骨钙素（OC）的影响，以及对腰椎骨密度（BMD）的影响。在24周后观察到AKG-Ca组平均CTX水平的最大降幅（37.0%，p = 0.006）。在12周和24周后，研究组之间CTX的差异具有统计学意义。OC血清水平不受治疗影响。AKG-Ca组的骨密度较基线水平增加了1.6%；然而，治疗组之间的差异估计为0.9%（无统计学意义）。这项研究表明AKG-Ca对患有骨质减少的绝经后女性具有潜在的益处。AKG-Ca可引起血清CTX的有益变化，这与维持腰椎骨量一致；然而，其长期效果仍需进一步研究。
