Berntson Lillemor, Wernroth Lisa, Fasth Anders, Aalto Kristiina, Herlin Troels, Nielsen Susan, Nordal Ellen, Rygg Marite, Zak Marek
Department of Women's and Children's Health, Uppsala University Children's Hospital, Uppsala, Sweden.
J Rheumatol. 2007 Oct;34(10):2106-11. Epub 2007 Sep 15.
Variables for assessment of disease activity of juvenile idiopathic arthritis (JIA) were studied, in order to develop a disease activity score for children with JIA.
One randomly chosen hospital visit was studied for each of 312 patients with JIA, with regard to disease activity variables. The physician global assessment score visual analog scale (physician GA) was used as a dependent variable in comparisons between potential disease activity variables. Previous studies have shown this variable to be the most sensitive to changes in JIA disease activity and to be comparable between patients.
Based on Spearman's rank order correlation the number of active joints had a strong association with the physician GA. The median physician GA score rose markedly for each active large joint, but less for small joints, although small joints were also statistically important in assessing disease activity. Among the laboratory data, the erythrocyte sedimentation rate, C-reactive protein level, and platelet count showed weak correlations to the physician GA.
In preparation of a disease activity score for children with JIA the importance of both the number and size of joints involved needs further evaluation.
研究用于评估幼年特发性关节炎（JIA）疾病活动度的变量，以便为JIA患儿制定疾病活动度评分。
对312例JIA患者中的每一位，就疾病活动度变量研究一次随机选择的医院就诊情况。在潜在疾病活动度变量的比较中，将医生整体评估视觉模拟量表评分（医生GA）用作因变量。先前的研究表明，该变量对JIA疾病活动度的变化最为敏感，且在患者之间具有可比性。
基于斯皮尔曼等级相关分析，活动关节数与医生GA有很强的相关性。每个活跃的大关节会使医生GA评分中位数显著上升，但小关节的影响较小，尽管小关节在评估疾病活动度方面在统计学上也很重要。在实验室数据中，红细胞沉降率、C反应蛋白水平和血小板计数与医生GA的相关性较弱。
在为JIA患儿制定疾病活动度评分时，受累关节的数量和大小的重要性都需要进一步评估。
