Sage J I, Mark M H
Department of Neurology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, New Brunswick 08903.
Ann Neurol. 1991 Oct;30(4):616-7. doi: 10.1002/ana.410300417.
We report the clinical response of a parkinsonian patient with severe motor fluctuations who was begun on continuous, nighttime-only levodopa infusions accompanied by oral carbidopa/levodopa use during the day. Sleep disturbances improved immediately. There was a gradual reduction in "off" time and severity of dyskinesias during the waking day. Nighttime-only levodopa infusions have a carryover benefit to the waking hours and may be suitable for long-term therapy to reduce daily motor fluctuations in some patients with Parkinson's disease.
我们报告了一名帕金森病患者的临床反应，该患者存在严重的运动波动，开始接受仅在夜间进行的左旋多巴持续输注治疗，白天同时使用口服卡比多巴/左旋多巴。睡眠障碍立即得到改善。清醒时的“关”期时间和异动症严重程度逐渐降低。仅在夜间进行左旋多巴输注对清醒时间有延续性益处，可能适用于某些帕金森病患者的长期治疗，以减少日常运动波动。
