Rabey J M, Grynberg E, Graff E
Department of Neurology, Sackler School of Medicine, Tel-Aviv University, Israel.
Ann Neurol. 1991 Dec;30(6):847-50. doi: 10.1002/ana.410300616.
We compared the muscarinic cholinergic binding in lymphocytes of 44 patients with idiopathic Parkinson's disease with 23 age-matched normal volunteers, using [3H]quinuclidinyl benzilate. In 24 patients with Parkinson's disease without dementia, binding was normal in 12, below control values in 6, whereas the remaining 6 (all on anticholinergic medication) showed very high binding. In all 20 patients with Parkinson's disease and with dementia, the binding was below control levels, indicating that in these patients, as in patients with Alzheimer's dementia, the cholinergic muscarinic binding by lymphocytes is reduced.
我们使用[3H]喹核醇基苯甲酸酯，比较了44例特发性帕金森病患者与23名年龄匹配的正常志愿者淋巴细胞中的毒蕈碱胆碱能结合情况。在24例无痴呆的帕金森病患者中，12例结合正常，6例低于对照值，而其余6例（均服用抗胆碱能药物）显示结合非常高。在所有20例患有帕金森病且伴有痴呆的患者中，结合低于对照水平，表明在这些患者中，如同患有阿尔茨海默病痴呆的患者一样，淋巴细胞的毒蕈碱胆碱能结合减少。
