Dubois B, Ruberg M, Javoy-Agid F, Ploska A, Agid Y
Brain Res. 1983 Dec 12;288(1-2):213-8. doi: 10.1016/0006-8993(83)90096-3.
CAT activity was decreased in the frontal cortex and the substantia innominata of parkinsonian subjects, post-mortem. The decrease was greater in the frontal cortex of parkinsonians with dementia. The density of muscarinic cholinergic receptors increased in the cortex. This increase was inversely correlated with tremor. The effects on these parameters of both neuronal degeneration and anticholinergic therapy are discussed.
尸检发现，帕金森病患者额叶皮质和无名质中的CAT活性降低。在患有痴呆症的帕金森病患者的额叶皮质中，这种降低更为明显。皮质中毒蕈碱胆碱能受体的密度增加。这种增加与震颤呈负相关。文中讨论了神经元变性和抗胆碱能治疗对这些参数的影响。
