Ruberg M, Ploska A, Javoy-Agid F, Agid Y
Brain Res. 1982 Jan 28;232(1):129-39. doi: 10.1016/0006-8993(82)90615-1.
[3H]Quinuclidinylbenzilate ([3H]QNB) binding and choline acetyltransferase (CAT) activity were studied in post-mortem brains from control and Parkinsonian subjects. CAT levels were reduced in the cortex and hippocampus of Parkinsonians. The apparent affinity of [3H]QNB for the muscarinic receptor was higher in both the caudate nucleus and the frontal cortex. Receptor density increased only in the frontal cortex. These changes are discussed in relation to dementia and mental disturbances following anticholinergic treatment frequently observed in Parkinson's disease.
研究了对照受试者和帕金森病患者死后大脑中[3H]奎宁环基苯甲酸酯（[3H]QNB）结合情况及胆碱乙酰转移酶（CAT）活性。帕金森病患者的皮质和海马体中CAT水平降低。在尾状核和额叶皮质中，[3H]QNB对毒蕈碱受体的表观亲和力均较高。仅额叶皮质中的受体密度增加。结合帕金森病中抗胆碱能治疗后常见的痴呆和精神障碍，对这些变化进行了讨论。
