• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

5-羟色胺7受体配体：最新进展与潜在治疗应用

5-HT7 receptor ligands: recent developments and potential therapeutic applications.

作者信息

Pittalà Valeria, Salerno Loredana, Modica Maria, Siracusa Maria Angela, Romeo Giuseppe

机构信息

Dipartimento di Scienze Farmaceutiche. Facoltà di Farmacia, Università di Catania, Viale A. Doria 6, 95125 Catania, Italy.

出版信息

Mini Rev Med Chem. 2007 Sep;7(9):945-60. doi: 10.2174/138955707781662663.

DOI:10.2174/138955707781662663
PMID:17897083
Abstract

The 5-HT(7) receptors (5-HT(7)Rs) are the most recent classified members of the serotonin family. Characterized in 1993, they belong to the G protein-coupled receptor family. Since their discovery, they have been the subject of intense research due to their widespread distribution in the brain, suggestive of multiple central roles. The focus of this review is to discuss the literature concerning recent advances on 5-HT(7)Rs and their ligands.

摘要

5-羟色胺（7）受体（5-HT(7)Rs）是血清素家族中最新分类的成员。它们于1993年被鉴定出来，属于G蛋白偶联受体家族。自发现以来，由于其在大脑中广泛分布，提示具有多种中枢作用，它们一直是深入研究的对象。本综述的重点是讨论有关5-HT(7)Rs及其配体的最新进展的文献。

相似文献

1
5-HT7 receptor ligands: recent developments and potential therapeutic applications.5-羟色胺7受体配体：最新进展与潜在治疗应用
Mini Rev Med Chem. 2007 Sep;7(9):945-60. doi: 10.2174/138955707781662663.
2
Latest advances towards the discovery of 5-HT(7) receptor ligands.朝着发现 5-HT(7) 受体配体的最新进展。
Mini Rev Med Chem. 2011 Nov;11(13):1108-21. doi: 10.2174/138955711797655353.
3
Serotonin 5-HT7 receptor agents: Structure-activity relationships and potential therapeutic applications in central nervous system disorders.5-羟色胺 5-HT7 受体激动剂：在中枢神经系统疾病中的结构-活性关系和潜在治疗应用。
Pharmacol Ther. 2011 Feb;129(2):120-48. doi: 10.1016/j.pharmthera.2010.08.013. Epub 2010 Oct 20.
4
Different regulation of rat 5-HT(2A) and rat 5-HT(2C) receptors in NIH 3T3 cells upon exposure to 5-HT and pipamperone.在暴露于5-羟色胺和匹泮哌隆后，NIH 3T3细胞中大鼠5-羟色胺2A受体和大鼠5-羟色胺2C受体的不同调节作用
Eur J Pharmacol. 2001 Aug 3;425(1):21-32. doi: 10.1016/s0014-2999(01)01170-0.
5
Neuropsychotoxicity of abused drugs: effects of serotonin receptor ligands on methamphetamine- and cocaine-induced behavioral sensitization in mice.滥用药物的神经心理毒性：5-羟色胺受体配体对小鼠甲基苯丙胺和可卡因诱导的行为敏化的影响。
J Pharmacol Sci. 2008 Jan;106(1):15-21. doi: 10.1254/jphs.fm0070121. Epub 2008 Jan 16.
6
Serotonin receptor ligands and the treatment of obesity.血清素受体配体与肥胖症治疗
Curr Opin Investig Drugs. 2004 Apr;5(4):377-88.
7
Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).高端血清素受体：5-羟色胺（5）、5-羟色胺（6）和5-羟色胺（7）。
J Med Chem. 2003 Jul 3;46(14):2795-812. doi: 10.1021/jm030030n.
8
Signaling at G-protein-coupled serotonin receptors: recent advances and future research directions.G蛋白偶联血清素受体的信号传导：最新进展与未来研究方向
Trends Pharmacol Sci. 2008 Sep;29(9):454-64. doi: 10.1016/j.tips.2008.06.007.
9
Studies on a series of potent, orally bioavailable, 5-HT(1) receptor ligands.关于一系列强效、口服生物可利用的5-羟色胺（1）受体配体的研究。
Bioorg Med Chem Lett. 2007 Sep 15;17(18):5214-7. doi: 10.1016/j.bmcl.2007.06.078. Epub 2007 Jun 30.
10
N-substituted-3-arylpyrrolidines: potent and selective ligands at serotonin 1A receptor.N-取代-3-芳基吡咯烷：强效且选择性的5-羟色胺1A受体配体。
Bioorg Med Chem Lett. 1999 May 17;9(10):1379-84. doi: 10.1016/s0960-894x(99)00201-2.

引用本文的文献

1
Serotonin Type 6 and 7 Receptors as a Novel Therapeutic Target for the Treatment of Schizophrenia.血清素6型和7型受体作为治疗精神分裂症的新型治疗靶点
Neuropsychiatr Dis Treat. 2020 Oct 28;16:2499-2509. doi: 10.2147/NDT.S263424. eCollection 2020.
2
Effect of the probiotic IS-10506 on BDNF and 5HT stimulation: role of intestinal microbiota on the gut-brain axis.益生菌IS-10506对脑源性神经营养因子（BDNF）和5-羟色胺（5HT）刺激的影响：肠道微生物群在肠-脑轴上的作用
Iran J Microbiol. 2019 Apr;11(2):145-150.
3
Effect of 5-HT7 receptor agonist, LP-211, on micturition following spinal cord injury in male rats.
5-羟色胺7受体激动剂LP-211对雄性大鼠脊髓损伤后排尿的影响。
Am J Transl Res. 2016 Jun 15;8(6):2525-33. eCollection 2016.
4
Serotonin 5-HT7 receptor agonist, LP-211, exacerbates Na(+), K(+)-ATPase/Mg(2+)-ATPase imbalances in spinal cord-injured male rats.血清素5-HT7受体激动剂LP-211会加剧脊髓损伤雄性大鼠体内钠、钾-ATP酶/镁-ATP酶失衡。
Diagn Pathol. 2015 Sep 14;10:157. doi: 10.1186/s13000-015-0397-7.
5
The arylpiperazine derivatives N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide and N-benzyl-4-(2-diphenyl)-1-piperazinehexanamide exert a long-lasting inhibition of human serotonin 5-HT7 receptor binding and cAMP signaling.芳基哌嗪衍生物 N-(4-氰基苯甲基)-4-(2-二苯基)-1-哌嗪己酰胺和 N-苄基-4-(2-二苯基)-1-哌嗪己酰胺对人血清素 5-HT7 受体结合和 cAMP 信号传导具有持久的抑制作用。
Pharmacol Res Perspect. 2013 Dec;1(2):e00013. doi: 10.1002/prp2.13. Epub 2013 Dec 5.
6
Towards metabolically stable 5-HT7 receptor ligands: a study on 1-arylpiperazine derivatives and related isosters.朝向代谢稳定的 5-HT7 受体配体：对 1-芳基哌嗪衍生物和相关同型物的研究。
Exp Brain Res. 2013 Oct;230(4):569-82. doi: 10.1007/s00221-013-3498-0. Epub 2013 Apr 10.
7
Serotonin 5-HT7 receptor agents: Structure-activity relationships and potential therapeutic applications in central nervous system disorders.5-羟色胺 5-HT7 受体激动剂：在中枢神经系统疾病中的结构-活性关系和潜在治疗应用。
Pharmacol Ther. 2011 Feb;129(2):120-48. doi: 10.1016/j.pharmthera.2010.08.013. Epub 2010 Oct 20.
8
Glioblastoma chemotherapy adjunct via potent serotonin receptor-7 inhibition using currently marketed high-affinity antipsychotic medicines.通过使用目前市售的高亲和力抗精神病药物抑制强效血清素受体-7，辅助胶质母细胞瘤的化学疗法。
Br J Pharmacol. 2010 Oct;161(3):481-7. doi: 10.1111/j.1476-5381.2010.00923.x.
9
LP-211 is a brain penetrant selective agonist for the serotonin 5-HT(7) receptor.LP-211 是一种穿透血脑屏障的选择性 5-羟色胺 5-HT(7)受体激动剂。
Neurosci Lett. 2010 Aug 30;481(1):12-6. doi: 10.1016/j.neulet.2010.06.036. Epub 2010 Jun 23.