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益生菌IS-10506对脑源性神经营养因子（BDNF）和5-羟色胺（5HT）刺激的影响：肠道微生物群在肠-脑轴上的作用

Effect of the probiotic IS-10506 on BDNF and 5HT stimulation: role of intestinal microbiota on the gut-brain axis.

作者信息

Ranuh Reza, Athiyyah Alpha Fardah, Darma Andy, Risky Vitria Prasetyo, Riawan Wibi, Surono Ingrid S, Sudarmo Subijanto Marto

机构信息

Department of Child Health, Dr. Soetomo Hospital, Faculty of Medicine Universitas Airlangga, Surabaya, Indonesia.

Department of Biomolecular Laboratory, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia.

出版信息

Iran J Microbiol. 2019 Apr;11(2):145-150.

DOI:
PMID:31341569
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6635314/
Abstract

BACKGROUND AND OBJECTIVES: Microbial communities residing in the gut play a major role in the communication between the gut and the brain through neural, immune, and hormonal routes. Changes in abundance of beneficial intestinal bacteria can affect health of individuals. Conversely, drugs, disease, diet and other factors can alter the gut microbiome. However, there is limited information on the effect of exogenous factors on gut microbiota. In this study, we investigated whether a beneficial bacterium, the probiotic IS-10506, can stimulate the gut-brain axis using Wistar rats. MATERIALS AND METHODS: The animals were divided into two groups: one received IS strain 10506 supplementation, while the control group received no treatment. Activation of the gut-brain axis was evaluated by immunohistochemical analysis of intestinal and brain serotonin (5-HT) and brain neurotrophin (NT), serotonin transporter (5-HTT), and brain-derived neurotrophic factor (BDNF) levels. RESULTS: The results showed that BDNF (< 0.000), NT (< 0.000007), and 5-HTT (< 0.000007) expression was upregulated in the brain along with intestinal 5-HT (< 0.000) level in rats treated with strain IS-10506 relative to the control group. CONCLUSION: The probiotic IS-10506 stimulates the gut-brain axis and can potentially promote brain development and function.

摘要

背景与目的：肠道内的微生物群落通过神经、免疫和激素途径在肠道与大脑的沟通中发挥着重要作用。有益肠道细菌数量的变化会影响个体健康。相反，药物、疾病、饮食和其他因素会改变肠道微生物群。然而，关于外源性因素对肠道微生物群影响的信息有限。在本研究中，我们使用Wistar大鼠研究了一种有益细菌——益生菌IS-10506是否能刺激肠-脑轴。 材料与方法：将动物分为两组：一组接受IS菌株10506补充剂，而对照组不接受任何处理。通过对肠道和大脑中血清素（5-HT）、脑神经营养因子（NT）、血清素转运体（5-HTT）和脑源性神经营养因子（BDNF）水平进行免疫组织化学分析，评估肠-脑轴的激活情况。 结果：结果显示，与对照组相比，用IS-10506菌株处理的大鼠大脑中BDNF（<0.000）、NT（<0.000007）和5-HTT（<0.000007）的表达上调，同时肠道5-HT（<0.000）水平也升高。 结论：益生菌IS-10506刺激肠-脑轴，可能促进大脑发育和功能。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36a9/6635314/f6e59655a825/IJM-11-145-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36a9/6635314/042094a3d6a2/IJM-11-145-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36a9/6635314/44b63eebb12f/IJM-11-145-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36a9/6635314/3b66522a8ad4/IJM-11-145-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36a9/6635314/22ab0c1ebb3c/IJM-11-145-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36a9/6635314/e17e9cb6f5d4/IJM-11-145-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36a9/6635314/c2a66315bec2/IJM-11-145-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36a9/6635314/dad66fdc4d6a/IJM-11-145-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36a9/6635314/86b55e707590/IJM-11-145-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36a9/6635314/ea73eae0dfe2/IJM-11-145-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36a9/6635314/32bfe8be8e40/IJM-11-145-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36a9/6635314/bcf5d54ca139/IJM-11-145-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36a9/6635314/f6e59655a825/IJM-11-145-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36a9/6635314/042094a3d6a2/IJM-11-145-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36a9/6635314/44b63eebb12f/IJM-11-145-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36a9/6635314/3b66522a8ad4/IJM-11-145-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36a9/6635314/22ab0c1ebb3c/IJM-11-145-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36a9/6635314/e17e9cb6f5d4/IJM-11-145-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36a9/6635314/c2a66315bec2/IJM-11-145-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36a9/6635314/dad66fdc4d6a/IJM-11-145-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36a9/6635314/86b55e707590/IJM-11-145-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36a9/6635314/ea73eae0dfe2/IJM-11-145-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36a9/6635314/32bfe8be8e40/IJM-11-145-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36a9/6635314/bcf5d54ca139/IJM-11-145-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36a9/6635314/f6e59655a825/IJM-11-145-g012.jpg

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