Gibbs Ayana A, Naudts Kris H, Spencer Edgar P, David Anthony S
Section of Cognitive Neuropsychiatry, Division of Psychological Medicine, Institute of Psychiatry, P.O. Box 68, De Crespigny Park, London, UK SE5 8AF.
Am J Psychiatry. 2007 Oct;164(10):1603-9; quiz 1624. doi: 10.1176/appi.ajp.2007.06081241.
Cognitive models suggest that biased processing of emotional information may play a role in the genesis and maintenance of psychotic symptoms. The role of dopamine and dopamine antagonists in the processing of such information remains unclear. The authors investigated the effect of a dopamine antagonist on perception of, and memory for, emotional information in healthy volunteers.
Thirty-three healthy male volunteers were randomly assigned to a single-blind intervention of either a single dose of the dopamine D(2)/D(3) antagonist amisulpride or placebo. An attentional blink task and an emotional memory task were then administered to assess the affective modulation of attention and memory, respectively.
A significant interaction was observed between stimulus valence and drug on recognition memory accuracy; further contrasts revealed enhanced memory for aversive-arousing compared with neutral stimuli in the placebo but not the amisulpride group. No effect of amisulpride was observed on the perception of emotional stimuli.
Amisulpride abolished the enhanced memory for emotionally arousing stimuli seen in the placebo group but had no effect on the perception of such stimuli. These results suggests that dopamine plays a significant role in biasing memory toward emotionally salient information and that dopamine antagonists may act by attenuating this bias.
认知模型表明，对情绪信息的偏差处理可能在精神病性症状的发生和维持中起作用。多巴胺和多巴胺拮抗剂在这类信息处理中的作用仍不明确。作者研究了多巴胺拮抗剂对健康志愿者情绪信息感知和记忆的影响。
33名健康男性志愿者被随机分配到单盲干预组，分别给予单剂量的多巴胺D(2)/D(3)拮抗剂氨磺必利或安慰剂。然后进行注意力瞬脱任务和情绪记忆任务，分别评估注意力和记忆的情感调节。
在识别记忆准确性方面，观察到刺激效价与药物之间存在显著交互作用；进一步对比发现，与中性刺激相比，安慰剂组对厌恶唤起刺激的记忆增强，但氨磺必利组未出现这种情况。未观察到氨磺必利对情绪刺激感知有影响。
氨磺必利消除了安慰剂组中对情绪唤起刺激增强的记忆，但对这类刺激的感知没有影响。这些结果表明，多巴胺在使记忆偏向情绪突出信息方面起重要作用，多巴胺拮抗剂可能通过减弱这种偏向起作用。
